Concentrated Growth Factors Extracted from Blood Plasma Used to Repair Nasal Septal Mucosal Defect After Rhinoplasty

Zhao QM, Gao J, Huang XX, Chen XP, Wang X.

What this paper says

Ten women with holes in the lining of the nasal septum after rhinoplasty were treated with concentrated growth factors from their own blood, and all healed after 3 to 12 treatments with no recurrence over 3 to 6 months.

Overview

Rhinoplasty can leave a defect in the mucosa lining the septum, which risks a hole developing through the septum itself. This preliminary study used concentrated growth factor, prepared from each patient's own blood, applied both as an injected liquid and as a membrane over the wound.

Sections of note

10 women with mucosal defects of the nasal septum, enrolled May 2017 to May 2018.
Liquid and gel concentrated growth factor were prepared from each patient's own blood sample using a Medifuge benchtop centrifuge system.
After debridement of the defect, liquid growth factor was injected around the wound and a membranous film applied to the surface.
Vaseline gauze was used to pack the nostrils.
Treatment was given at intervals of 3 to 5 days.
After 3 to 12 treatments all patients achieved successful repair, with good appearance and function.
No recurrence was observed during 3 to 6 months of follow-up. Level of evidence IV.

What it means for a patient

The material comes from the patient's own blood, spun down at the clinic, so nothing foreign is introduced.
Treatment took between 3 and 12 sessions spaced a few days apart.
All ten healed and none reopened within the follow-up period.
Limits: 10 patients, all women, single group with no comparison, and follow-up of 3 to 6 months, which is short for judging whether a lining defect stays closed.

Why this paper matters

Mucosal defects can progress to a full septal perforation, which is difficult to repair surgically, so a non-surgical route to closure would be valuable. Ten consecutive successes are encouraging. Without a control group it is unclear how many would have healed on their own.

Terms

Concentrated growth factor: A preparation from the patient's own blood containing healing factors.
Nasal septum: The central wall of cartilage and bone dividing the nose.
Mucosa: The moist lining covering the inside of the nose.
Debridement: Cleaning away damaged or dead tissue from a wound.
Septal perforation: A hole passing all the way through the septum.

Summary written by rhinoplasty.cc from the abstract, 2026-09-09; not medical advice. The authors' own abstract follows.

From the abstract

“To assess preliminarily the effect of concentrated growth factor (CGF) for repair of nasal septal mucosal defect after rhinoplasty. Methods: Ten women with mucosal defects of the nasal septum were enrolled from May 2017 to May 2018. Liquid and gel CGF was prepared from each patient's blood sample using a Medifuge…”

Excerpt; the full abstract is on PubMed.