Non-surgical Rhinoplasty with Hyaluronic acid Fillers: Predictable Results Using Software for the Evaluation of Nasal Angles

Santorelli A, Marlino S.

What this paper says

Across 62 patients treated with a mean 0.55 mL of hyaluronic acid filler, the nasofrontal angle rose by 3.7 degrees and satisfaction from 2.4 to 9.4 out of 10, with minor transient complications in under 5 percent.

Overview

Evidence on which filler products and techniques suit the nose is limited. This prospective single-center study treated the bridge and the strip between the nostrils with two specific hyaluronic acid products and measured the resulting angle changes using free software.

Sections of note

Prospective, open-label, single-center study of consecutive adults treated in the bony and cartilaginous bridge and the columella with VYC-20 or VYC-17.5; maximum 1 mL used.
All patients except one had at least 12 months of follow-up.
62 patients enrolled, 57 female and 5 male; mean age 29.0 years SD 9.2.
Mean filler injected at first treatment 0.55 mL SD 0.22, range 0.2 to 1.0 mL; 12 patients required a touch-up of 0.15 mL SD 0.08.
Mean nasofrontal angle rose from 143.6 degrees SD 6.3 to 147.3 SD 6.7, a change of 3.7 SD 2.8.
Mean nasolabial angle rose from 85.3 degrees SD 6.1 to 88.5 SD 6.1, a change of 3.2 SD 2.6.
Satisfaction on a 0 to 10 scale rose from 2.4 SD 1.7 to 9.4 SD 0.8; complications were minor and transient: pain 3 (4.8%), swelling 3 (4.8%), bruise 2 (3.2%). Level of evidence IV.

What it means for a patient

Small filler volumes, around half a millilitre, produced measurable angle changes of roughly 3 to 4 degrees.
Roughly 1 in 5 patients needed a small top-up.
No serious vascular complications occurred in this series, though the nose carries that recognized risk.
Limits: 62 patients, one center, no comparison group, and satisfaction measured on an unvalidated 0 to 10 scale.

Why this paper matters

Nasal filler outcomes are usually described rather than measured, and this pairs angle measurement with product and volume specifics. Twelve months of follow-up addresses duration, which most filler papers omit. The absence of a control group and of a validated satisfaction instrument limits the conclusions.

Terms

Hyaluronic acid filler: An injectable gel that can be dissolved with an enzyme if needed.
Nasofrontal angle: The angle between the forehead and the bridge of the nose.
Nasolabial angle: The angle between the base of the nose and the upper lip.
Columella: The strip of tissue between the nostrils.
Open-label: A study in which participants and investigators know what treatment is given.

Summary written by rhinoplasty.cc from the abstract, 2026-09-09; not medical advice. The authors' own abstract follows.

From the abstract

“There is a relative lack of evidence on optimal products and techniques for nose treatment with hyaluronic acid (HA) fillers. This study assessed the efficacy and safety of nasal reshaping with Vycross HA fillers, using a free software (Face Master) to measure facial parameters. Methods: This was a prospective,…”

Excerpt; the full abstract is on PubMed.